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Adium is a free instant messaging application for Mac OS X that can connect to AIM, MSN, Jabber, Yahoo, and more.

Multi-protocol Proteus is an Instant Messenger that uses the IM framework libpurple and is written using Mac OS X's API Cocoa. Proteus attempts to bridge the gap between functionality and beauty, using native the Mac interface with a powerful core to get your hard core instant messaging done.

Fliq is a powerful, feature-rich desktop utility for exchanging contacts, photos, notes, to do items and documents with other Fliq users. Fliq works seamlessly with applications like Microsoft Outlook, Windows Contacts, iPhoto, iCal and Address Book.