Seasons Wellness

increased inflammatory markers associated with increased hot flash severity in menopausal women.  This is also associated with increased cardiovascular disease. Interesting that progesterone has anti-inflammatory properties.  So, therapy to reduce hot flashes should include inflammation reduction.

elevated insulin in insulin resistance decreases circulating Natriuretic peptide.  This provides a direct link between obesity and cardiovascular disease

Progesterone is known to have anti-inflammatory action.  This study looked at the anti-inflammatory action of progesterone on the myometrium of the uterus during pregnancy.  The anti-inflammatory effect, in this study, was through Progesterone Receptor B.  There was a change in the dominance to PR A late in pregnancy.  This would promote inflammatory signaling and thus contractions with the onset of labor.

high leptin, high PTH, fibroblastic growth factor, and bone alkaline phosphatase associated with obesity.

826 research articles on Vitamin D

Vitamin D deficiency may play a role in autism.  Though this may seem logical, through NF-KappaB inhibition, the mode of protection may be more in pregnancy.  I believe that the in-utero environment is setting up our children for increased ASD rates.  Then add in the manner in which we treat our children as infants with massive vaccinations.

Finally, something that lowers the risk associated with synthetic progestins. Progestins are progesterone pretenders that increase breast cancer. Apigenin, a component of bioflavonoid, was shown to inhibit growth and intact cause cell death.

Not surprising, but nice to see in study.  Dr. McTiernan showed that weight loss as little as 5% reduces breast cancer risk.  The reason?  Decreased Testosterone production in women due to insulin resistance and decreased fat for aromatase conversion of Testosterone to Estradiol and decreased androstenedione to estrone.  This study confirms the importance of the obesity epidemic to health.

DDE in hispanic farm workers found to be inversely associated with testosterone.  Again, DDE and other persistent organohalogen pollutants, work to lower testosterone in men.

Review finds endocrine disruption from Organocholrides, also called persistent organohalogen pollutants. Common POP, would be DDE, DDT...

This is a review of several cohorts, but this follows the rest of the literature that these environmental toxicants are endocrine disruptors.

High DDE levels in African American men associated with a 23% lower Testosteone levels

testosterone gel as effect, and better tolerated, than patch in androgen replacement in men.

new CDC guidelines lower lead toxicity levels in children.  CDC: " there is no safe level of blood lead in children".  If no level is safe in children, what about other age groups?

I look forward to the published results of this study as this abstract references the WHI as the "same entry" criteria.  I imagine the HRT would be the same too, but will wait to see.  There is a serious problem with proper reporting of synthetic estrogens as bioidentical estrogens and synthetic progestins as bioidentical progesterone;  Also, what is the dosage. Most individuals are massively overdosed.  This study was said to be a "landmark".  Could just be don't use synthetic hormones: which is what the WHI said.

higher cruciferous vegetable intake associated with improved breast cancer survival rates according to Shanghai Breast Cancer Survival Study.

overweight and obesity associated with higher risk of prostate cancer recurrence.  No surprise here.  Excess fat will increase inflammatory cytokines and aromatase conversion of Testosterone to Estradiol: also producing inflammation.

this study revealed increased breast cancer risk in women on "estrogen" and "testosterone" therapy.  Now, several problems here: first, are these synthetic hormone or bioidentical.  Second, the dosages appear, in what is written, to be supra physiologic.  Third, giving supra physiologic estradiol and testosterone will obviously create imbalances and growth potential.  Fourth, how were the women evaluated prior to starting hormone therapy and then were they remonitered (unlikely), fifth, were hormone metabolites evaluated (too, also unlikely).  This study has serious flaws and very little can be extrapolated other than: don't take supra physiologic hormone levels without appropriate evaluation.  Enough said

weight loss results in reduced IL-6, CRP, and other markers of inflammation.

documented cadmium sites in Louisiana

cadmium increases growth potential of breast cancer.  No surprise, cadmium is a classic endocrine disruptor that mimics estrogen.