- Last active: on 24 Oct 09
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- Owner: Tomasz Kotarba
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- Group category: Science
Women With Breast Cancer Have Low Vitamin D Levels - 0 views
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"ScienceDaily (Oct. 8, 2009) - Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center."
Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency. Weekly supplementation with high doses of vitamin D -- 50,000 international units or more -- improved the levels, according to Peppone's study.
The U.S. Institute of Medicine suggests that blood levels nearing 32 nanograms per milliliter are adequate.
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids - Journal of ... - 0 views
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Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ.
J Clin Invest. 2007 Jul;117(7):1866-75.
PMID: 17607361
Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer.
Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women wit... - 0 views
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Israeli 'cancer shift' over heart disease mortality may be led by greater risk in women with high intake of n-6 fatty acids.
Shapira N.
Eur J Cancer Prev. 2007 Oct;16(5):486-94.
PMID: 17923822
doi: 10.1097/CEJ.0b013e3280145b6d
Population studies of Israeli Jews, Arabs, and women support the association of high n-6 polyunsaturated fatty acid intake with increased cancer risk and higher female sensitivity. Research findings suggest that gender and sex hormones may influence n-6 polyunsaturated fatty acid metabolism and carcinogenesis. This appears to be the first time gender has been proposed to modulate national cancer epidemiology, suggesting implications for differential nutritional prevention, warranting further research.
Experimental Drug May Work In Many Cancers - 1 views
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"SCIENTISTS have shown that a new class of cancer drugs called PARP inhibitors, currently being tested in clinical trials to treat breast and ovarian cancer could have dramatic results when used to treat other solid tumours, according to work presented at the NCRI Cancer Conference today. "
Factors Associated With Clinical Benefit From Epidermal Growth Factor Receptor Inhibitors i... - 0 views
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Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck.
Cohen EE, Halpern AB, Kasza K, Kocherginsky M, Williams R, Vokes EE.
Oral Oncol. 2009 Oct;45(10):e155-60. Epub 2009 Jul 7.
PMID: 19586795
Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 coun... - 0 views
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Relationship between low ultraviolet B irradiance and higher breast cancer risk in 107 countries.
Mohr SB, Garland CF, Gorham ED, Grant WB, Garland FC.
Breast J. 2008 May-Jun;14(3):255-60. Epub 2008 Apr 17.
PMID: 18422861
DOI: 10.1111/j.1524-4741.2008.00571.x
There was a protective effect of UVB irradiance on risk of breast cancer that was independent of fertility rate, proportion of the population overweight, alcohol intake, animal energy intake, and other covariates.
Vitamin D for Cancer Prevention: Global Perspective - 1 views
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Vitamin D for cancer prevention: global perspective.
Garland CF, Gorham ED, Mohr SB, Garland FC.
Ann Epidemiol. 2009 Jul;19(7):468-83. Review.
PMID: 19523595
RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
Vitamin D and prevention of breast cancer: pooled analysis. - ScienceDirect - The Journal o... - 0 views
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Vitamin D and prevention of breast cancer: pooled analysis.
Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
PMID: 17368188
CONCLUSIONS: Intake of 2000 IU/day of Vitamin D(3), and, when possible, very moderate exposure to sunlight, could raise serum 25(OH)D to 52 ng/ml, a level associated with reduction by 50% in incidence of breast cancer, according to observational studies.
Christiane Northrup, MD: Protect Your Breasts With Vitamin D - 0 views
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"A study conducted by Cedric Garland and other prominent vitamin D researchers determined that women with vitamin D levels above 52 ng/ml have half the risk of developing breast cancer as those with 13 ng/ml! Garland (et al) estimates that 58,000 new cases of breast cancer in the U.S. could be prevented per year by raising vitamin D levels to 52 ng/ml. Imagine what the global impact could be! "
Breast Cancer Around The World - TIME - 0 views
How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation a... - 0 views
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How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
Vieth R.
Anticancer Res. 2009 Sep;29(9):3675-84. Review.
PMID: 19667164
Incident Invasive Breast Cancer, Geographic Location of Residence, and Reported Average Tim... - 0 views
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ncident invasive breast cancer, geographic location of residence, and reported average time spent outside.
Millen AE, Pettinger M, Freudenheim JL, Langer RD, Rosenberg CA,
Mossavar-Rahmani Y, Duffy CM, Lane DS, McTiernan A, Kuller LH, Lopez AM, Wactawski-Wende J.
Cancer Epidemiol Biomarkers Prev. 2009 Feb;18(2):495-507. Epub 2009 Feb 3.
PMID: 19190147
doi: 10.1158/1055-9965.EPI-08-0652
In conclusion, region of residence and geographic solar irradiance are not consistently related to risk of breast cancer and may not be sufficient proxy measures for sunlight/vitamin D exposure. The observed association between time spent outside and breast cancer risk support the hypothesis that vitamin D may protect against breast cancer.
The Relevance of Vitamin D Receptor (VDR) Gene Polymorphisms for Cancer: A Review of the Li... - 0 views
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The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature.
Köstner K, Denzer N, Müller CS, Klein R, Tilgen W, Reichrath J.
Anticancer Res. 2009 Sep;29(9):3511-36. Review.
PMID: 19667145
CONCLUSION: Significant associations with VDR polymorphisms have been reported in cancer of the breast (Fok1, Bsm1, Taq1, Apa1, poly (A)), prostate (Fok1, Bsm1, Taq1, poly (A)), skin (Fok1, Bsm1, A-1210), colorectum (Fok1, Bsm1), ovary (Fok1, Apa1) and bladder (Fok1), and in renal cell carcinoma (Taq1, Apa1). However, conflicting data have been reported for most malignancies. After careful evaluation of the actual literature, it can be summarized that data indicating an association of VDR polymorphisms and cancer risk are strongest for breast cancer (Bsm1, Fok1), prostate cancer (Fok1) and malignant melanoma (MM) (Fok1). Data indicating an association of VDR polymorphisms and cancer prognosis are strongest for prostate cancer (Fok1), breast cancer (Bsm1, Taq1), MM (Bsm1) and renal cell carcinoma (Taq1).
A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortal... - 0 views
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A multicountry ecologic study of risk and risk reduction factors for prostate cancer mortality.
Grant WB.
Eur Urol. 2004 Mar;45(3):271-9.
PMID: 15036670
CONCLUSIONS: These results are consistent with insulin-like growth factor-I (IGF-I), being an important risk factor for prostate cancer, with alcohol and calcium being less important risk factors, and with allium family vegetables, and, to a lesser extent, vitamin D being important risk reduction factors. These results should provide guidance for additional studies on dietary and environmental links to prostate cancer.
Review Article: Vitamin D Acquisition and Breast Cancer Risk -- Pérez-López et al... - 0 views
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Review article: vitamin D acquisition and breast cancer risk.
Pérez-López FR, Chedraui P, Haya J.
Reprod Sci. 2009 Jan;16(1):7-19. Review.
PMID: 19144887
DOI: 10.1177/1933719108327595
Conclusions: Although there are controversial results, it seems plausible that sufficient endogenous vitamin D levels may have a protective function on mammary cells, reducing breast cancer risk.
Association between Plasma 25-Hydroxyvitamin D and Breast Cancer Risk -- Crew et al. 2 (6):... - 0 views
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Association between plasma 25-hydroxyvitamin D and breast cancer risk.
Crew KD, Gammon MD, Steck SE, Hershman DL, Cremers S, Dworakowski E, Shane E, Terry MB, Desai M, Teitelbaum SL, Neugut AI, Santella RM.
Cancer Prev Res (Phila Pa). 2009 Jun;2(6):598-604. Epub 2009 May 26.
PMID: 19470790
In summary, these results add to a growing body of evidence that adequate vitamin D stores may prevent breast cancer development. Whereas circulating 25-OHD levels of >32 ng/mL are associated with normal bone mineral metabolism, our data suggest that the optimal level for breast cancer prevention is ≥40 ng/mL. Well-designed clinical trials are urgently needed to determine whether vitamin D supplementation is effective for breast cancer chemoprevention.
Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin and Do... - 0 views
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Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
DOI: 10.1177/0115426507022003305
Calcium, Dairy Foods, Vitamin D, and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer ... - 0 views
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Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
Mizoue T, Kimura Y, Toyomura K, Nagano J, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N.
Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2800-7.
PMID: 18843026
Vitamin D From Dietary Intake and Sunlight Exposure and the Risk of Hormone-Receptor-Define... - 0 views
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Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer.
Blackmore KM, Lesosky M, Barnett H, Raboud JM, Vieth R, Knight JA.
Am J Epidemiol. 2008 Oct 15;168(8):915-24. Epub 2008 Aug 27.
PMID: 18756015
doi:10.1093/aje/kwn198
This study suggests that vitamin D is associated with a reduced risk of breast cancer regardless of ER/PR status of the tumor. Future studies with a larger number of receptor-negative and mixed tumors are required.
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Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
PMID: 19851861
These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.